The Pan Am Protocol

The basis of the 15 day Pan Am Cancer Immunotherapy protocol is serially stimulating various arms of the immune system in order to generate a synergistic attack on the tumor. Our approach is based on “targeting tumors at different levels”.  Specifically, we aim to:

  1. Reduce tumor volume by direct killing of cancer cells with intravenous vitamin C;
  2. “Choke off” the blood supply to the tumor by inducing an immune response against the blood vessels that feed the tumor.
  3. Repair the dendritic cell compartment of the patient, which is essential in maintaining anticancer immunity; and d) stimulate the innate and adaptive immune response by administration of ImmunoMax and TCM, respectively

Intravenous Vitamin C

is administered as a direct anticancer agent.  Studies have shown that plasma concentrations of vitamin C achievable only by intravenous administration cause generation of localized hydrogen peroxide, which causes selective killing of tumor cells but spares non-malignant cells.

Dendritic cells (DC)

are considered to be gatekeepers of the immune response.  During healthy situations, DC remain in an immature state and protect the body’s tissue from attack by the immune system.  When patients become sick, DC mature and actively instruct the immune system to seek and destroy the pathogen causes sickness.  In cancer patients DC are “programmed” by the tumor to remain in an immature state.  This allows the tumor to grow without the immune response killing it.  In our treatment protocol we generate DC from the patient, activate them to mature in the lab, and subsequently re-administer them.  This stimulates the immune system to begin attacking the cancer.

ImmunoMax

is a plant derived activator of natural killer cells (NK).  Federally registered in Russia for use as an antiviral pharmaceutical, our collaborators have demonstrated potent anti-tumor activity of ImmunoMax in patients as well as in animal models.  Interestingly, treatment with ImmunoMax not only stimulates direct killing of tumors by NK cells but also causes elicitation of memory cytotoxic T cells, which patrol the body for micrometastasis.

TCM (T Cell Modulator)

is a small molecule peptide that was demonstrated to stimulate DC in the body.  This immune activator was used for over 20 years as an “adjuvant” to numerous vaccines in order to stimulate cell mediated immunity.  The utilization of TCM in combination with our DC protocol ensures that the cells remain in an activated state, which allows them to elicit maximal anti-tumor response.